Technical reports from the American Academy of Pediatrics benefit from expertise and
resources of liaisons and internal (AAP) and external reviewers. However, technical reports …

The correlation between epigenetics and human reproduction represents a very interesting
field of study, mainly due to the possible transgenerational effects related to epigenetic …

Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures
may play a critical role in early programming for childhood and adult illness. Maternal …

The period of in utero development is one of the most critical windows during which adverse
intrauterine conditions and exposures can influence the growth and development of the …

The concept of immunological memory stipulates that past exposures shape present
immune function. These exposures include not only specific antigens impacting adaptive …

Background Recent studies suggest that perfluoroalkyl substances (PFAS) and PFAS
alternatives can cross the placental barrier. However, little is known on the differential …

Currently, information regarding concentrations of chlorinated polyfluoroalkyl ether sulfonic
acids (Cl-PFESAs) in human placenta does not exist. The main objective of this study was to …

Every year in the United States, approximately 3500 infants die of sleep-related infant
deaths, including sudden infant death syndrome (SIDS)(International Statistical …

An adverse early-life environment is associated with long-term disease consequences.
Adversity early in life is hypothesized to elicit developmental adaptations that serve to …

Background There is evidence that altered DNA methylation is an important epigenetic
mechanism in prenatal programming and that developmental periods are sensitive to …