Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

The Future Role of Abdominal US in Hepatocellular Carcinoma Surveillance

M Mendiratta-Lala, D Fetzer, A Kamaya, ND Parikh… - Radiology, 2024 - pubs.rsna.org
Abdominal US is currently the best-validated surveillance strategy for hepatocellular
carcinoma (HCC) in at-risk patients. It is the only modality shown to have completed all five …

Hepatocellular carcinoma surveillance patterns and outcomes in patients with cirrhosis

D Daher, KS El Dahan, A Cano, M Gonzales… - Clinical …, 2024 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) surveillance is associated with
improved early detection and reduced mortality, although practice patterns and effectiveness …

The financial burden after liver transplantation is significant among commercially insured adults: A large US National Cohort

SR Lieber, Y Jiang, AR Jones, P Gowda… - Liver …, 2024 - journals.lww.com
Liver transplantation (LT) is lifesaving for patients with cirrhosis; however, the resultant
financial burden to patients has not been well characterized. We aimed to provide a …

Hepatocellular Carcinoma Screening in a Contemporary Cohort of At-Risk Patients

D Daher, KS El Dahan, NE Rich, N Tayob… - JAMA Network …, 2024 - jamanetwork.com
Importance Cohort studies demonstrating an association of hepatocellular carcinoma (HCC)
screening with reduced mortality are prone to lead-time and length-time biases. Objective To …

Cost-Effectiveness of a Biomarker-Based Screening Strategy for Hepatocellular Carcinoma in Patients with Cirrhosis

AG Singal, J Chhatwal, N Parikh, E Tapper - Liver Cancer, 2024 - karger.com
Introduction: Given suboptimal performance of ultrasound-based surveillance for early
hepatocellular carcinoma (HCC) detection in patients with cirrhosis, there is interest in …

Benefits and Harms of Hepatocellular Carcinoma Screening Outreach in Patients with Cirrhosis: A Multi-Center Randomized Clinical Trial

AG Singal, D Daher, M Narasimman… - JNCI: Journal of the …, 2024 - academic.oup.com
Background The value of hepatocellular carcinoma (HCC) screening is defined by the
balance of benefits from early tumor detection vs harms due to false positive results. We …

HES V2. 0 outperforms GALAD for detection of HCC: A phase 3 biomarker study in the United States

HB El-Serag, Q Jin, T Nabihah, E Salem, M Luster… - Hepatology, 2024 - journals.lww.com
Background: The original hepatocellular carcinoma early detection screening (HES) score,
which combines alpha-fetoprotein (AFP) with age, alanine aminotransferase, and platelets …

Proportion time covered by hepatocellular carcinoma surveillance in patients with cirrhosis

D Daher, KS El Dahan, S Yekkaluri… - Official journal of the …, 2022 - journals.lww.com
Background: Hepatocellular carcinoma (HCC) surveillance is associated with improved
early tumor detection, but effectiveness is limited by underuse. We characterized adherence …

Pragmatic strategies to address health disparities along the continuum of care in chronic liver disease

M Brahmania, S Rogal, M Serper, A Patel… - Hepatology …, 2024 - journals.lww.com
Racial, ethnic, and socioeconomic disparities exist in the prevalence and natural history of
chronic liver disease, access to care, and clinical outcomes. Solutions to improve health …