Multiangle Light Scattering as a Lentivirus Purification Process Analytical Technology
SA Sripada, E Barbieri, S Shastry… - Analytical …, 2024 - ACS Publications
The limited biomolecular and functional stability of lentiviral vectors (LVVs) for cell therapy
poses the need for analytical tools that can monitor their titers and activity throughout the …
poses the need for analytical tools that can monitor their titers and activity throughout the …
The downstream bioprocess toolbox for therapeutic viral vectors
Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
Peptide ligands for the universal purification of exosomes by affinity chromatography
RE Kilgore, BD Moore, SA Sripada… - Biotechnology and …, 2024 - Wiley Online Library
Exosomes are gaining prominence as vectors for drug delivery, vaccination, and
regenerative medicine. Owing to their surface biochemistry, which reflects the parent cell …
regenerative medicine. Owing to their surface biochemistry, which reflects the parent cell …
Serotype-agnostic affinity purification of adeno-associated virus (AAV) via peptide-functionalized chromatographic resins
Adeno-associated viruses (AAVs) have emerged as a prominent family of vectors for gene
delivery, providing therapeutic options to diseases once deemed incurable. At the same …
delivery, providing therapeutic options to diseases once deemed incurable. At the same …
Affinity chromatography for virus-like particle manufacturing: challenges, solutions, and perspectives
J Ma, Z Tian, Q Shi, X Dong, Y Sun - Journal of Chromatography A, 2024 - Elsevier
The increasing medical application of virus-like particles (VLPs), notably vaccines and viral
vectors, has increased the demand for commercial VLP production. However, VLP …
vectors, has increased the demand for commercial VLP production. However, VLP …
Peptide ligands for the affinity purification of adenovirus from HEK293 and vero cell lysates
Adenovirus (AdVs) is the viral vector of choice in vaccines and oncolytic applications owing
to its high transduction activity and inherent immunogenicity. For decades, AdV isolation has …
to its high transduction activity and inherent immunogenicity. For decades, AdV isolation has …
Discovery of broad-spectrum high-affinity peptide ligands of spike protein for the vaccine purification of SARS-CoV-2 and Omicron variants
J Ma, Y Huang, G Jia, X Dong, Q Shi, Y Sun - International Journal of …, 2024 - Elsevier
To combat with emerging SARS-CoV-2 variants of concern (VOCs), we report the
identification of a set of unique HWK-motif peptide ligands for the receptor-binding domain …
identification of a set of unique HWK-motif peptide ligands for the receptor-binding domain …