▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

The neurotrophin receptor TrkB is essential for normal function of the mammalian brain,,. It is
expressed in three splice variants. Full-length receptors (TrkBFL) possess an intracellular …

We determined the gene structure of the human TrkB gene. The gene is unusually large and
spans at least 590 kbp. It contains 24 exons. Using alternative promoters, splicing, and …

Neurotrophins belonging to the class of growth factors and including nerve growth factor
(NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin …

Steroid hormones fulfil important functions in animal development. In Drosophila, ecdysone
triggers moulting and metamorphosis through its effects on gene expression. Ecdysone …

Neurotrophins are important regulators of embryonic development and adult function of most
populations of neurons in vertebrate nervous systems. This signaling system regulates many …

Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …

Endocytosis of Trk (tropomyosin-related kinase) receptors is critical for neurotrophin signal
transduction and biological functions. However, the mechanism governing endocytosis of …