Cotranscriptional folding is an obligate step of RNA biogenesis that can guide RNA structure
formation and function through transient intermediate folds. This process is particularly …

RNAs begin to fold and function during transcription. Riboswitches undergo
cotranscriptional switching in the context of transcription elongation, RNA folding, and ligand …

Riboswitch architectures that involve the binding of a single ligand to a single RNA aptamer
domain result in ordinary dose-response curves that require approximately a 100-fold …

Aptamer-based regulatory biosensors can dynamically regulate the expression of target
genes in response to ligands and could be used in dynamic metabolic engineering for …

Riboswitches function as important translational regulators in bacteria. Comprehensive
mutational analysis of transcriptional riboswitches has been used to probe the energetic …

Background In vivo biosensors have a wide range of applications, ranging from the
detection of metabolites to the regulation of metabolic networks, providing versatile tools for …

The sequences of the 5′ untranslated regions (5′-UTRs) of mRNA alter gene expression
across domains of life. Transcriptional modulators can be easily assayed through …

Since their discovery, riboswitches have been attractive tools for the user-controlled
regulation of gene expression in bacterial systems. Riboswitches facilitate small molecule …

Glycine riboswitches utilize both single-and tandem-aptamer architectures. In the tandem
system, the relative contribution of each aptamer toward gene regulation is not well …

Ligand specificity is an essential requirement for all riboswitches. Some variant riboswitches
utilize a common structural motif, yet through subtle sequence differences, they are able to …