Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

The elevated risk of Parkinson's disease in patients with diabetes might be mitigated
depending on the type of drugs prescribed to treat diabetes. Population data for risk of …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

In recent years, an emerging body of evidence has forged links between Parkinson's
disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with …

Epidemiological studies of Parkinson's disease (PD) show variable and partially conflicting
findings with regard to incidence, prevalence, and mortality. These differences are …

Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …

Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in
the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts …

ABSTRACT Background Type 2 diabetes (T2DM) is an established risk factor for developing
Parkinson's disease (PD), but its effect on disease progression is not well understood …