Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Polyamines are low molecular weight, aliphatic polycations found in the cells of all living
organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA …

In contrast to other members of the Eag family of voltage-gated, outwardly rectifying
potassium channels, the human eag-related gene (HERG) has now been shown to encode …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

In recent years the functions of polyamines (putrescine, spermidine, and spermine) have
been studied at the molecular level. Polyamines can modulate the functions of RNA, DNA …

The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …