The link between circulating follicular helper T cells and autoimmunity
LSK Walker - Nature Reviews Immunology, 2022 - nature.com
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
The science and medicine of human immunology
B Pulendran, MM Davis - Science, 2020 - science.org
BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …
detection and neutralization of pathogens. History is replete with the devastating effects of …
Accelerated waning of the humoral response to COVID-19 vaccines in obesity
AA Van Der Klaauw, EC Horner, P Pereyra-Gerber… - Nature Medicine, 2023 - nature.com
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-
19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 …
19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 …
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …
with fewer hospitalizations and often milder disease than in adults. A subset of children …
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
JM Kastenschmidt, S Sureshchandra, A Jain… - Immunity, 2023 - cell.com
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …
advance informed vaccine design, it is critical that we understand the cellular dynamics …
“World in motion”–emulsion adjuvants rising to meet the pandemic challenges
Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …
key components of licensed vaccines, with over 100 million doses administered to diverse …
CD4+ T cells that help B cells–a proposal for uniform nomenclature
T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice
A Silva-Cayetano, WS Foster, S Innocentin… - Med, 2021 - cell.com
Background The spread of SARS-CoV-2 has caused a worldwide pandemic that has
affected almost every aspect of human life. The development of an effective COVID-19 …
affected almost every aspect of human life. The development of an effective COVID-19 …
Surgical trauma‐induced immunosuppression in cancer: recent advances and the potential therapies
F Tang, Y Tie, C Tu, X Wei - Clinical and translational medicine, 2020 - Wiley Online Library
Surgical resection remains the mainstay treatment for solid cancers, especially for localized
disease. However, the postoperative immunosuppression provides a window for cancer cell …
disease. However, the postoperative immunosuppression provides a window for cancer cell …