Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Acetylation is a posttranslational modification conserved in all domains of life that is carried
out by N-acetyltransferases. While acetylation can occur on N α-amino groups, this review …

Macrophages undergo metabolic changes during activation that are coupled to functional
responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

Malonylation is a recently identified post-translational modification with malonyl-coenzyme A
as the donor. It conserved both in prokaryotes and eukaryotes. Recent advances in the …

As a newly discovered post-translational modification (PTM), lysine malonylation (Kmal)
regulates a myriad of cellular processes from prokaryotes to eukaryotes and has important …

The analysis of the post-translational modification (PTM) state of proteins using mass
spectrometry-based bottom-up proteomic workflows has evolved into a powerful tool for the …

Pseudomonas aeruginosa is a multi-drug-resistant human opportunistic pathogen largely
involved in nosocomial infections. Unfortunately, effective antibacterial agents are lacking …

Lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to be an evolutionarily
conserved histone mark. Here, we report that CobB serves as a lysine de-2 …

Histone crotonylation is a new lysine acylation type of post-translational modification (PTM)
enriched at active gene promoters and potential enhancers in yeast and mammalian cells …