The eukaryotic genome is organized in the three-dimensional nuclear space in a specific
manner that is both a cause and a consequence of its function. This organization is partly …

Enhancer function underlies regulatory processes by which cells establish patterns of gene
expression. Recent results suggest that many enhancers are specified by particular …

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
creates a significant threat to global health. Recent studies suggested the significance of …

Over the past decade there has been a greater understanding of genomic complexity in
eukaryotes ushered in by the immense technological advances in high-throughput …

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

Although repetitive elements pervade mammalian genomes, their overall contribution to
transcriptional activity is poorly defined. Here, as part of the FANTOM4 project, we report that …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear
architecture are regulated by RNA signalling. Although the precise molecular mechanisms …