The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Developing synapses mature through the recruitment of specific proteins that stabilize
presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

The molecular and cellular mechanisms underlying complex axon morphogenesis are still
poorly understood. We report a novel, evolutionary conserved function for the Drosophila …

Mutations in some cell adhesion molecules (CAMs) cause abnormal synapse formation and
maturation, and serve as one of the potential mechanisms of autism spectrum disorders …

Down syndrome (DS) is caused by trisomy 21, and it is characterized by developmental
brain disorders and neurological dysfunction. Clinical studies and basic research have …

The ability of neurites of the same neuron to avoid each other (self-avoidance) is a
conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the …

Deubiquitylating enzymes (DUBs) antagonize ubiquitination by removing ubiquitin from their
substrates. The role of DUBs in controlling various physiological and pathological processes …