The substrate repertoire of γ-secretase/presenilin
G Güner, SF Lichtenthaler - Seminars in cell & developmental biology, 2020 - Elsevier
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
[HTML][HTML] Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
New insights into the molecular mechanisms of axon guidance receptor regulation and signaling
As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
[HTML][HTML] γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
LJ Restrepo, AT DePew, ER Moese, SR Tymanskyj… - Developmental cell, 2022 - cell.com
Developing synapses mature through the recruitment of specific proteins that stabilize
presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) …
presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) …
[HTML][HTML] To stick or not to stick: The multiple roles of cell adhesion molecules in neural circuit assembly
T Moreland, FE Poulain - Frontiers in Neuroscience, 2022 - frontiersin.org
Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …
development, axons respond to diverse cues present in the extracellular matrix or at the …
[HTML][HTML] Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed
The molecular and cellular mechanisms underlying complex axon morphogenesis are still
poorly understood. We report a novel, evolutionary conserved function for the Drosophila …
poorly understood. We report a novel, evolutionary conserved function for the Drosophila …
[HTML][HTML] DSCAM deficiency leads to premature spine maturation and autism-like behaviors
Mutations in some cell adhesion molecules (CAMs) cause abnormal synapse formation and
maturation, and serve as one of the potential mechanisms of autism spectrum disorders …
maturation, and serve as one of the potential mechanisms of autism spectrum disorders …
[HTML][HTML] Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids
Down syndrome (DS) is caused by trisomy 21, and it is characterized by developmental
brain disorders and neurological dysfunction. Clinical studies and basic research have …
brain disorders and neurological dysfunction. Clinical studies and basic research have …
[HTML][HTML] Confluence and convergence of Dscam and Pcdh cell-recognition codes
The ability of neurites of the same neuron to avoid each other (self-avoidance) is a
conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the …
conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the …
[HTML][HTML] Insights into the properties, biological functions, and regulation of USP21
T An, Y Lu, X Yan, J Hou - Frontiers in Pharmacology, 2022 - frontiersin.org
Deubiquitylating enzymes (DUBs) antagonize ubiquitination by removing ubiquitin from their
substrates. The role of DUBs in controlling various physiological and pathological processes …
substrates. The role of DUBs in controlling various physiological and pathological processes …