Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect

K Tsutsui, T Ubuka, GE Bentley, LJ Kriegsfeld - General and comparative …, 2012 - Elsevier
A hypothalamic neuropeptide, gonadotropin-releasing hormone (GnRH), is the primary
factor regulating gonadotropin secretion. An inhibitory hypothalamic neuropeptide for …

A journey through the gonadotropin-inhibitory hormone system of fish

JA Muñoz-Cueto, JA Paullada-Salmerón… - Frontiers in …, 2017 - frontiersin.org
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that belongs to the
RFamide peptide family and was first identified in the quail brain. From the discovery of …

Origin and evolution of the neuroendocrine control of reproduction in vertebrates, with special focus on genome and gene duplications

S Dufour, B Quérat, H Tostivint… - Physiological …, 2020 - journals.physiology.org
In humans, as in the other mammals, the neuroendocrine control of reproduction is ensured
by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are …

Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

T Ubuka, YL Son, K Tsutsui - General and comparative endocrinology, 2016 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that was isolated
from the brains of Japanese quail in 2000, which inhibited luteinizing hormone release from …

Gonadotropin-inhibitory hormone (GnIH): A new key neurohormone controlling reproductive physiology and behavior

K Tsutsui, T Ubuka - Frontiers in Neuroendocrinology, 2021 - Elsevier
The discovery of novel neurohormones is important for the advancement of
neuroendocrinology. In early 1970s, gonadotropin-releasing hormone (GnRH), a …

RFamide peptides as mediators in environmental control of GnRH neurons

I Parhar, S Ogawa, T Kitahashi - Progress in Neurobiology, 2012 - Elsevier
Hypothalamic gonadotropin-releasing hormone (GnRH) is a key hormone for reproductive
functions in vertebrates and non-vertebrates. Although GnRH neuronal system is regulated …

Gonadotropin-inhibitory hormone-stimulation of food intake is mediated by hypothalamic effects in chicks

B McConn, G Wang, J Yi, ER Gilbert, T Osugi, T Ubuka… - Neuropeptides, 2014 - Elsevier
Abstract Gonadotropin-inhibitory hormone (GnIH), a 12 amino acid peptide, is expressed in
the avian brain and inhibits luteinizing hormone secretion. Additionally, exogenous injection …

Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior

K Tsutsui, T Ubuka, K Ukena - Frontiers in Neuroendocrinology, 2022 - Elsevier
The discovery of gonadotropin-inhibitory hormone (GnIH) in 2000 has led to a new research
era of reproductive neuroendocrinology because, for a long time, researchers believed that …

Contribution of GnIH research to the progress of reproductive neuroendocrinology

K Tsutsui, T Ubuka, YL Son, GE Bentley… - Frontiers in …, 2015 - frontiersin.org
Since the discovery of gonadotropin-releasing hormone (GnRH) in mammals at the
beginning of the 1970s, it was generally accepted that GnRH is the only hypothalamic …

How to contribute to the progress of neuroendocrinology: discovery of GnIH and progress of GnIH research

K Tsutsui, T Ubuka - Frontiers in endocrinology, 2018 - frontiersin.org
It is essential to discover novel neuropeptides that regulate the functions of pituitary, brain
and peripheral secretory glands for the progress of neuroendocrinology. Gonadotropin …