Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is a monogenic, yet highly phenotypically variable disease with
multisystem pathology. This manuscript provides an overview of many of the known …

Sickle cell disease (SCD) is characterized by deoxygenation–induced polymerization of
hemoglobin in red blood cells, leading to hemolytic anemia, vaso–occlusion, and the …

Sickle cell disease (SCD) patients are at a four-to 100-fold increased risk for thrombosis
compared with the general population, although the mechanisms and risk factors are not …

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a mutation in the
sixth amino acid of the β-globin gene (HBB). It is the most common serious genetic diseases …

Progress in the care of sickle cell disease (SCD) has been hampered by the extreme
complexity of the SCD phenotype despite its monogenic inheritance. While epidemiological …

Hyperbilirubinemia in patients with sickle cell anemia (SCA) as a result of enhanced
erythrocyte destruction, lead to cholelithiasis development in a subset of patients. Evidence …

Lactate dehydrogenase (LDH) activity is elevated in many pathological states. Interest in
LDH activity in sickle cell disease (SCD) has developed out of an increased comprehension …

Cerebrovascular disease (CVD) is a severe complication associated with sickle cell anemia.
Abnormal transcranial Doppler (TCD) identifies some children at high risk, but other markers …