Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy

G Cheng - Advanced drug delivery reviews, 2015 - Elsevier
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that regulate numerous
biological processes by targeting a broad set of messenger RNAs. Recently, miRNAs have …

[HTML][HTML] Tumor-associated circulating microRNAs as biomarkers of cancer

J Wang, KY Zhang, SM Liu, S Sen - Molecules, 2014 - mdpi.com
MicroRNAs (miRNAs), the 17-to 25-nucleotide long noncoding RNAs that modulate the
expression of mRNAs and proteins, have emerged as critical players in cancer initiation and …

Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs

A Mahajan, D Sapehia, S Thakur, PS Mohanraj… - Scientific reports, 2019 - nature.com
DNA methylation, a central component of the epigenetic network is altered in response to
nutritional influences. In one-carbon cycle, folate acts as a one-carbon carrier and vitamin …

Circulating microRNAs in hepatocellular carcinoma: potential diagnostic and prognostic biomarkers

H Reza Mirzaei, A Sahebkar… - Current …, 2016 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is one of the most common types of malignancies
worldwide. There is little information on the mechanisms involved in the pathogenesis of this …

Circulating microRNAs, miR-939, miR-595, miR-519d and miR-494, identify cirrhotic patients with HCC

F Fornari, M Ferracin, D Trerè, M Milazzo, S Marinelli… - PloS one, 2015 - journals.plos.org
The performance of circulating biomarkers for the diagnosis of hepatocellular carcinoma
(HCC) is sub-optimal. In this study we tested circulating microRNAs as biomarkers for HCC …

Circulating microRNA biomarkers as liquid biopsy for cancer patients: pros and cons of current assays

S Ono, S Lam, M Nagahara, DSB Hoon - Journal of clinical medicine, 2015 - mdpi.com
An increasing number of studies have focused on circulating microRNAs (cmiRNA) in
cancer patients' blood for their potential as minimally-invasive biomarkers. Studies have …

Recent advances in duplex-specific nuclease-based signal amplification strategies for microRNA detection

Y Wu, S Cui, Q Li, R Zhang, Z Song, Y Gao… - Biosensors and …, 2020 - Elsevier
In recent years, miRNAs had emerged as promising biomarkers for diagnosis and prognosis
of the health-threatening diseases (eg, cancers), which associated with a broad range of …

Cell‐free microRNAs in blood and other body fluids, as cancer biomarkers

B Ortiz‐Quintero - Cell proliferation, 2016 - Wiley Online Library
The discovery of cell‐free micro RNA s (mi RNA s) in serum, plasma and other body fluids
has yielded an invaluable potential source of non‐invasive biomarkers for cancer and other …

[HTML][HTML] Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

W Okajima, S Komatsu, D Ichikawa… - World Journal of …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), with its high incidence and mortality rate, is one of the
most common malignant tumors. Despite recent development of a diagnostic and treatment …