Reactive oxygen species (ROS) have long been studied as destructive agents in the context
of nervous system ageing, disease and degeneration. Their roles as signalling molecules …

Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

A proper balance between chemical reduction and oxidation (known as redox balance) is
essential for normal cellular physiology. Deregulation in the production of oxidative species …

Actin is one of the most abundant proteins in eukaryotic cells and the main component of the
microfilament system. It plays essential roles in numerous cellular activities, including …

Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling
inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper …

Historically, ROS have been considered toxic molecules, especially when their intracellular
concentration reaches high values. However, physiological levels of ROS support crucial …

Reactive oxygen species (ROS), which were originally classified as exclusively deleterious
compounds, have gained increasing interest in the recent years given their action as bona …

Abstract The small RhoGTPase Rac1 is implicated in a variety of events related to actin
cytoskeleton rearrangement. Remarkably, another event that is completely different from …

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of
cells throughout the body. While multiple proteins have been characterized as affecting actin …

Reactive oxygen species (ROS) have been extensively studied as damaging agents
associated with ageing and neurodegenerative conditions. Their role in the nervous system …