In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Acute Lymphoblastic Leukemia | New England Journal of Medicine Skip to main content Access
provided by Charite - Universitaetsmedizin Berlin The New England Journal of Medicine …

Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …

Identical infant twins with concordant leukemia were first described in 1882, and since that
time many such pairs of infants and older children have been described. It has long been …

Chromosome translocations are often early or initiating events in leukaemogenesis,
occurring prenatally in most cases of childhood leukaemia. Although these genetic changes …

Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically
heterogeneous lymphoid neoplasms derived from B-and T-lymphoid progenitors. Diagnosis …

Childhood leukemia is the most common cause of malignancy under the age of 15,
representing an annual incidence rate of 43 cases per million in the United States …

Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …