During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

From the earliest stages of embryonic development, cells of epithelial and mesenchymal
origin contribute to the structure and function of developing organs. However, these …

Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …

Background In preimplantation mouse embryos, the first cell fate specification to the
trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is …

Genetic studies have identified the key signalling pathways and developmentally regulated
transcription factors that govern cell lineage allocation and axis patterning in the early …

Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell
polarity. The cell polarity established in early embryos prefigures the macroscopic …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

Primitive endoderm (PE) and epiblast (EPI) are two lineages derived from the inner cell
mass (ICM) of the E3. 5 blastocyst. Recent studies showed that EPI and PE progenitors …

The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we
show that Pax6 is uniformly expressed in early NE cells of human fetuses and those …

In vitro embryo production (IVP) in cattle has gained worldwide interest in recent years, but
the efficiency of using IVP embryos for calf production is far from optimal. This review will …