The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Recent findings have provided a molecular basis for the combined contributions of
multifaceted risk factors for the onset of multiple sclerosis (MS). MS appears to start as a …

Background: Per-and polyfluoroalkyl substances (PFAS) are environmentally persistent
chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is …

Background Prenatal air pollution exposure has been linked to many adverse health
conditions in the offspring. However, little is known about the mechanisms underlying these …

The chances to develop Alzheimer's disease (AD) result from a combination of genetic and
non-genetic risk factors, the latter likely being mediated by epigenetic mechanisms. In the …

Background Prenatal exposure to phthalates has been associated with adverse health and
neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins, which strongly argues for …

Identifying the effects of genetic variation on the epigenome in disease-relevant cell types
can help advance our understanding of the first molecular contributions of genetic …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

Background The variation in multiple sclerosis (MS) disease severity is incompletely
explained by genetics, suggesting genetic and environmental interactions are involved …