Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

TNA Gunawardena, MT Rahman… - Journal of tissue …, 2019 - Wiley Online Library
Recent studies suggest that the main driving force behind the therapeutic activity observed
in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These …

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

D Garnier, O Renoult, MC Alves-Guerra, F Paris… - Frontiers in …, 2019 - frontiersin.org
Over the years, substantial evidence has definitively confirmed the existence of cancer stem-
like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem …

Delivery of exogenous miR-124 to glioblastoma multiform cells by Wharton's jelly mesenchymal stem cells decreases cell proliferation and migration, and confers …

S Sharif, MH Ghahremani, M Soleimani - Stem cell reviews and reports, 2018 - Springer
MicroRNAs (miRs) are potential therapeutic targets in glioblastoma multiforme (GBM), but
the difficulties associated with their delivery to tumor target cells have hampered their …

The tumor microenvironment's gambit: Exosomal pawns on the board of head and neck cancer

S Mohamadi, P Mehrasa, B Mehramuz… - … et Biophysica Acta (BBA …, 2024 - Elsevier
The tumor microenvironment (TME) harbors a hidden universe of interactions that
profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely …

[HTML][HTML] Mesenchymal stem cells in glioblastoma therapy and progression: How one cell does it all

B Nowak, P Rogujski, M Janowski, B Lukomska… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Mesenchymal stem cells (MSCs) are among the most investigated and applied somatic stem
cells in experimental therapies for the regeneration of damaged tissues. Moreover, as it was …

Microvascular experimentation in the chick chorioallantoic membrane as a model for screening angiogenic agents including from gene-modified cells

DC Kennedy, B Coen, AM Wheatley… - International journal of …, 2021 - mdpi.com
The chick chorioallantoic membrane (CAM) assay model of angiogenesis has been
highlighted as a relatively quick, low cost and effective model for the study of pro-angiogenic …

Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo

LF Pavon, TT Sibov, AV de Souza, EF da Cruz… - Stem Cell Research & …, 2018 - Springer
Background Previous studies have demonstrated remarkable tropism of mesenchymal stem
cells (MSCs) toward malignant gliomas, making these cells a potential vehicle for delivery of …

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

A Bajetto, S Thellung, I Dellacasagrande… - Stem Cells …, 2020 - academic.oup.com
Mesenchymal stem cells (MSCs) can be isolated from bone marrow or other adult tissues
(adipose tissue, dental pulp, amniotic fluid, and umbilical cord). In vitro, MSCs grow as …

Application of mesenchymal stem cells in targeted delivery to the brain: potential and challenges of the extracellular vesicle-based approach for brain tumor treatment

AD Do, I Kurniawati, CL Hsieh, TT Wong… - International journal of …, 2021 - mdpi.com
Treating brain tumors presents enormous challenges, and there are still poor prognoses in
both adults and children. Application of novel targets and potential drugs is hindered by the …