[PDF][PDF] A simple guide to de novo transcriptome assembly and annotation

V Raghavan, L Kraft, F Mesny… - Briefings in …, 2022 - academic.oup.com
A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily
attainable proxy catalog of protein-coding genes when genome assembly is unnecessary …

The evolution of insect biodiversity

E Tihelka, C Cai, M Giacomelli, J Lozano-Fernandez… - Current Biology, 2021 - cell.com
Insects comprise over half of all described animal species. Together with the Protura
(coneheads), Collembola (springtails) and Diplura (two-pronged bristletails), insects form …

DALI shines a light on remote homologs: One hundred discoveries

L Holm, A Laiho, P Törönen, M Salgado - Protein Science, 2023 - Wiley Online Library
Structural comparison reveals remote homology that often fails to be detected by sequence
comparison. The DALI web server (http://ekhidna2. biocenter. helsinki. fi/dali) is a platform …

OrthoDB v11: annotation of orthologs in the widest sampling of organismal diversity

D Kuznetsov, F Tegenfeldt, M Manni… - Nucleic Acids …, 2023 - academic.oup.com
OrthoDB provides evolutionary and functional annotations of genes in a diverse sampling of
eukaryotes, prokaryotes, and viruses. Genomics continues to accelerate our exploration of …

Accurate prediction of protein structures and interactions using a three-track neural network

M Baek, F DiMaio, I Anishchenko, J Dauparas… - Science, 2021 - science.org
DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

Conformational ensembles of the human intrinsically disordered proteome

G Tesei, AI Trolle, N Jonsson, J Betz, FE Knudsen… - Nature, 2024 - nature.com
Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …

eggNOG 6.0: enabling comparative genomics across 12 535 organisms

A Hernández-Plaza, D Szklarczyk, J Botas… - Nucleic Acids …, 2023 - academic.oup.com
The eggNOG (evolutionary gene genealogy Non-supervised Orthologous Groups) database
is a bioinformatics resource providing orthology data and comprehensive functional …

Phylogenomics reveals the history of host use in mosquitoes

J Soghigian, C Sither, SA Justi, G Morinaga… - Nature …, 2023 - nature.com
Mosquitoes have profoundly affected human history and continue to threaten human health
through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has …

Inference of phylogenetic trees directly from raw sequencing reads using Read2Tree

D Dylus, A Altenhoff, S Majidian, FJ Sedlazeck… - Nature …, 2024 - nature.com
Current methods for inference of phylogenetic trees require running complex pipelines at
substantial computational and labor costs, with additional constraints in sequencing …

TFLink: an integrated gateway to access transcription factor–target gene interactions for multiple species

O Liska, B Bohár, A Hidas, T Korcsmáros, B Papp… - Database, 2022 - academic.oup.com
Abstract Analysis of transcriptional regulatory interactions and their comparisons across
multiple species are crucial for progress in various fields in biology, from functional …