Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

The emergence of phase separation as an organizing principle in bacteria

CA Azaldegui, AG Vecchiarelli, JS Biteen - Biophysical journal, 2021 - cell.com
Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

T Ni, Q Jiang, PC Ng, J Shen, H Dou, Y Zhu… - Nature …, 2023 - nature.com
Carboxysomes are a paradigm of self-assembling proteinaceous organelles found in nature,
offering compartmentalisation of enzymes and pathways to enhance carbon fixation. In α …

Advances in the bacterial organelles for CO2 fixation

LN Liu - Trends in Microbiology, 2022 - cell.com
Carboxysomes are a family of bacterial microcompartments (BMCs), present in all
cyanobacteria and some proteobacteria, which encapsulate the primary CO 2-fixing …

A catalog of the diversity and ubiquity of bacterial microcompartments

M Sutter, MR Melnicki, F Schulz, T Woyke… - Nature …, 2021 - nature.com
Bacterial microcompartments (BMCs) are organelles that segregate segments of metabolic
pathways which are incompatible with surrounding metabolism. BMCs consist of a …

Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus

RQ Zhou, YL Jiang, H Li, P Hou, WW Kong, JX Deng… - Nature Plants, 2024 - nature.com
Carboxysomes are bacterial microcompartments that encapsulate the enzymes RuBisCO
and carbonic anhydrase in a proteinaceous shell to enhance the efficiency of photosynthetic …

α-carboxysome size is controlled by the disordered scaffold protein CsoS2

LM Oltrogge, AW Chen, T Chaijarasphong… - Biochemistry, 2023 - ACS Publications
Carboxysomes are protein microcompartments that function in the bacterial CO2
concentrating mechanism (CCM) to facilitate CO2 assimilation. To do so, carboxysomes …

Electrochemical cofactor recycling of bacterial microcompartments

M Sutter, LM Utschig, J Niklas, S Paul… - Proceedings of the …, 2024 - pnas.org
Bacterial microcompartments (BMCs) are prokaryotic organelles that consist of a protein
shell which sequesters metabolic reactions in its interior. While most of the substrates and …

[HTML][HTML] Protein stoichiometry, structural plasticity and regulation of bacterial microcompartments

LN Liu, M Yang, Y Sun, J Yang - Current Opinion in Microbiology, 2021 - Elsevier
Highlights•Bacterial microcompartments (BMCs) are self-assembling organelles comprising
a protein shell that encapsulates cargo enzymes.•Unraveling the composition and …

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells

D Sarkar, C Maffeo, M Sutter, A Aksimentiev… - Proceedings of the …, 2024 - pnas.org
Carboxysomes are protein microcompartments found in cyanobacteria, whose shell
encapsulates rubisco at the heart of carbon fixation in the Calvin cycle. Carboxysomes are …