The yeast deletion collection: a decade of functional genomics

G Giaever, C Nislow - Genetics, 2014 - academic.oup.com
The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …

[HTML][HTML] Thermotolerant fermenting yeasts for simultaneous saccharification fermentation of lignocellulosic biomass

J Choudhary, S Singh, L Nain - Electronic Journal of Biotechnology, 2016 - Elsevier
Lignocellulosic biomass is the most abundant renewable source of energy that has been
widely explored as second-generation biofuel feedstock. Despite more than four decades of …

A global genetic interaction network maps a wiring diagram of cellular function

M Costanzo, B VanderSluis, EN Koch, A Baryshnikova… - Science, 2016 - science.org
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER

BG Wong, CP Mancuso, S Kiriakov, CJ Bashor… - Nature …, 2018 - nature.com
Precise control over microbial cell growth conditions could enable detection of minute
phenotypic changes, which would improve our understanding of how genotypes are shaped …

[HTML][HTML] Cellular control of viscosity counters changes in temperature and energy availability

LB Persson, VS Ambati, O Brandman - Cell, 2020 - cell.com
Cellular functioning requires the orchestration of thousands of molecular interactions in time
and space. Yet most molecules in a cell move by diffusion, which is sensitive to external …

Functional metabolomics describes the yeast biosynthetic regulome

M Mülleder, E Calvani, MT Alam, RK Wang… - Cell, 2016 - cell.com
Genome-metabolism interactions enable cell growth. To probe the extent of these
interactions and delineate their functional contributions, we quantified the Saccharomyces …

rDNA array length is a major determinant of replicative lifespan in budding yeast

M Hotz, NH Thayer, DG Hendrickson… - Proceedings of the …, 2022 - National Acad Sciences
The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …

Genetic effects on molecular network states explain complex traits

M Weith, J Großbach, M Clement‐Ziza… - Molecular Systems …, 2023 - embopress.org
The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Modifying yeast tolerance to inhibitory conditions of ethanol production processes

L Caspeta, T Castillo, J Nielsen - Frontiers in Bioengineering and …, 2015 - frontiersin.org
Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid
substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory …

Considerations for the use of transcriptomics in identifying the 'genes that matter'for environmental adaptation

TG Evans - The Journal of experimental biology, 2015 - journals.biologists.com
Transcriptomics has emerged as a powerful approach for exploring physiological responses
to the environment. However, like any other experimental approach, transcriptomics has its …