Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

Proteases are fundamental for a plethora of biological processes, including signalling and
tissue remodelling, and dysregulated proteolytic activity can result in pathogenesis. In this …

Maintenance of normal epithelial ion and water transport in the lungs includes providing a
thin layer of surface liquid that coats the conducting airways. This airway surface liquid is …

Background Acute lung injury (ALI) is characterized by suppressed fibrinolytic activity in
bronchoalveolar lavage fluid (BALF) attributed to elevated plasminogen activator inhibitor-1 …

Aim In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active
plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to …

Aim Activation of sodium reabsorption by urinary proteases has been implicated in sodium
retention associated with nephrotic syndrome. The study was designed to test the …

The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating
proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC …

Stroke is a major public health issue, corresponding to the second cause of mortality and the
first cause of severe disability. Ischemic stroke is the most common type of stroke …

The plasminogen system is important for fibrinolysis in addition to tissue remodeling and
inflammation with significance for kidney disease. The system consists of the circulating …