Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

The Monro-Kellie doctrine is a well-accepted principle of intracranial hemodynamics. It has
undergone few consequential revisions since it was established. Its principle is …

Acute intracerebral hemorrhage (ICH) is a devastating type of stroke worldwide. Neuronal
destruction involved in the brain damage process caused by ICH includes a primary injury …

Cerebral perfusion pressure (CPP) is normally expressed by the difference between mean
arterial blood pressure (MAP) and intracranial pressure (ICP) but comparison of the …

Background: Cerebral edema after large hemispheric infarction is associated with poor
functional outcome and mortality. Net water uptake (NWU) quantifies the degree of …

Background Invasive intracranial pressure (ICP) monitoring is a standard practice in severe
brain injury cases, where it allows to derive cerebral perfusion pressure (CPP); ICP-tracing …

BACKGROUND: After a large intracerebral hemorrhage (ICH), the hematoma and swelling
cause intracranial pressure (ICP) to increase, sometimes causing brain herniation and …

Intracranial tumors pose a challenge in neurosurgery, especially when patients present
emergently or require emergency surgery. Tackling an acute change in the patient's mental …

Rising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death
following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that …

Therapeutic hypothermia (TH) has applications dating back millennia. In modern history,
however, TH saw its importation into medical practice where investigations have …