Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …

Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogeneous
cell population is a daunting challenge. Here, we show that microfluidic devices can be used …

Artificial stimuli-responsive surfaces that can mimic the dynamic function of living systems
have attracted much attention. However, there exist few artificial systems capable of …