Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Gout is the most prevalent form of inflammatory arthritis, with a strong impact on individual
health and healthcare systems. This article reviews clinical and experimental evidences …

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases
including type 2 diabetes and shortened lifespan. However, the impact of obesity and water …

Tumor-induced host wasting and mortality are general phenomena across species. Many
groups have previously demonstrated endocrinal impacts of malignant tumors on host …

In most organisms, dietary restriction (DR) increases lifespan. However, several studies
have found that genotypes within the same species vary widely in how they respond to DR …

Objectives MicroRNAs (miRNAs) are short single-stranded RNAs that play a role in the post-
transcriptional regulation of gene expression. Their deregulation can be associated with …

Abstract Bombyx mori Linnaeus, 1758 (Lepidoptera: Bombycidae), a very important
economical insect and backbone of the silk industry, is fully reliant on humans for its life …

Precise coupling between cellular physiology and metabolism is emerging as a vital
relationship underpinning tissue health and longevity. Nevertheless, functional-metabolic …

This study aims to explore the protective effects of quercetin against cadmium-induced
nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly …

Gut microbiota impacts the host metabolome and affects its health span. How bacterial
species in the gut influence age-dependent metabolic alteration has not been elucidated …