Melatonin is a ubiquitous natural neurotransmitter-like compound produced primarily by the
pineal gland. This agent is involved in numerous aspects of the biological and physiologic …

The high incidence of age-related diseases in the increasing population of elderly people
has stimulated interest in the search for protective agents that have the capability of …

Oral Diseases (2010) 16, 242–247 Background: Melatonin is the principal secretory product
of the pineal gland. It has immunomodulatory and antioxidant activities, stimulates the …

In the present review we summarize the relationship between the amino acid, tryptophan,
the neurotransmitter, serotonin, and the indole, melatonin, with the rhythms of sleep/wake …

Endocrine-immune system interactions have been widely demonstrated in mammals,
whereas in fish, these relationships remain unclear. Of the organs that constitute the …

Aging is known to alter the circadian rhythms of melatonin, serotonin, thermoregulatory
responses, cytokine production, and sleep/wakefulness which affect sleep quality. We tested …

The aim of the present study was to understand the rhythmic changes in innate immune
response in freshwater fish Channa punctatus. Furthermore, the putative role of melatonin …

Ageing is associated with an increased production of free radicals and alterations in the
mechanisms of adaptation to oxidative stress. In fact, the free radical theory of ageing …

Melatonin is involved in the regulation of both cellular and humoral immunity. In the present
study we have evaluated the effect of the oral administration of melatonin and its precursor …

A functional connection between the pineal gland (via the hormone melatonin) and the
immune system has been suggested. In our previous results in the ring dove, we observed …