The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Immunotherapy using checkpoint inhibitors is one of the most promising current cancer
treatment strategies. However, in breast cancer, its success has been limited to a subset of …

Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to
invasive breast cancer (IBC). To understand the changes in the tumor microenvironment …

Background Colorectal cancer (CRC) is one of the most common malignant tumours. The
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and
metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs) …

The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive.
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …

Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages
cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth …

During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …