In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of
human in vitro models of neurological disease. The iPS-derived and differentiated cells …

Exosomes are extracellular vesicles that can transfer biological information over long
distances affecting normal and pathological processes throughout organism. It is known that …

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals
worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem …

Angelman syndrome (AS) is a neurogenetic disorder caused by deletion of the maternally
inherited UBE3A allele and is characterized by developmental delay, intellectual disability …

The pharmaceutical industry is facing unprecedented challenges as the cost of developing
new drugs has reached unsustainable levels, fueled in large parts by a high attrition rate in …

Stem cell‐derived neurons from various source materials present unique model systems to
examine the fundamental properties of central nervous system (CNS) development as well …

Neural circuits are the underlying functional units of the human brain that govern complex
behavior and higher-order cognitive processes. Disruptions in neural circuit development …

Animal models of neurodevelopmental disorders have provided invaluable insights into the
molecular-, cellular-, and circuit-level defects associated with a plethora of genetic …

Neurological disorders affect millions of Americans and this number is expected to rise with
the aging population. Development of drugs to treat these disorders may be facilitated by …

Induced pluripotent stem cell (iPSC)-derived neurons permit the study of neurogenesis and
neurological disease in a human setting. However, the electrophysiological properties of …