Nanoscale objects, whether of biologic origin or synthetically created, are being developed
into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications …

Conceptual and methodological issues relevant to cytokine an... : Current Opinion in
Clinical Nutrition & Metabolic Care Conceptual and methodological issues relevant to …

Aspects of immune system dysregulation associated with long-duration spaceflight have yet
to be fully characterized and may represent a clinical risk to crewmembers during deep …

Abstract Purpose: Interleukin-6 (IL-6) facilitates cancer cell survival via pleotrophic effects.
We conducted a multicenter phase II study of CNTO328 (siltuximab) as second-line therapy …

Objective We investigated whether rheumatoid arthritis (RA)-related autoantibodies were
associated with systemic inflammation in a prospective cohort of first-degree relatives …

Recognition of intracellular bacteria by macrophages leads to secretion of type I IFNs.
However, the role of type I IFN during bacterial infection is still poorly understood …

Currently available therapies for rheumatoid arthritis (RA) are inadequate to alleviate the
inflammation and reduce joint damage. While the immune-regulatory effect of human …

In the drive to develop drugs with well-characterized and clinically monitorable safety
profiles, there is incentive to expand the repertoire of safety biomarkers for toxicities without …

Background Glioblastoma (GBM) is an aggressive infiltrative brain tumor with a particularly
poor prognosis that is characterized by microvascular proliferation, necrotic tissue, and …

CD4+ T cell subsets play an important role in the adaptive immune response in human
autoimmune diseases and in animal models of autoimmunity. In recent years, our …