The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …

The unconventional T cell compartment encompasses a variety of cell subsets that straddle
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …

Severe COVID-19 is characterized by excessive inflammation of the lower airways. The
balance of protective versus pathological immune responses in COVID-19 is incompletely …

BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …

Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)
continuously inform lymphocytes on changes in drained tissues. Here, using LN …

Abstract Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …

Unconventional T cells are a diverse and underappreciated group of relatively rare
lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly …