The ocular lens has a very high content of the antioxidant glutathione (GSH) and the
enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It …

Structural analysis of protein tyrosine phosphatases (PTPs) has expanded considerably in
the last several years, producing more than 200 structures in this class of enzymes (from 35 …

Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

EGF is an essential growth factor needed for epithelial cell proliferation and wound healing
of the cornea, but the molecular mechanism is not understood. Although studies have shown …

Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as
therapeutic targets. Recent reports suggest low–molecular weight PTP (LMPTP)—encoded …

NF-κB is a family of important transcription factors involved in many cellular functions, such
as cell survival, proliferation, and stress responses. Many studies indicate that NF-κB is a …

Purpose.: To study the effect of age on the morphologic and biochemical alterations induced
by in vivo exposure of ultraviolet radiation (UV). Methods.: Young and old C57BL/6 mice …

Oxidative post-translational modifications (oxPTM) of receptors, enzymes, ion channels and
transcription factors play an important role in cell signaling. oxPTMs are a key way in which …

Originally identified as a low molecular weight acid phosphatase, LMW-PTP is actually a
protein tyrosine phosphatase that acts on many phosphotyrosine-containing cellular …

Although promising, the ability to regulate angiogenesis through delivery of VEGF remains
an unrealized goal. We have shown previously that physiological levels of peroxynitrite (1 …