Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Tocotrienol as a potential anticancer agent

MT Ling, SU Luk, F Al-Ejeh, KK Khanna - Carcinogenesis, 2012 - academic.oup.com
Vitamin E is composed of two structurally similar compounds: tocopherols (TPs) and
tocotrienols (T3). Despite being overshadowed by TP over the past few decades, T3 is now …

A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases

NZ Ramli, MF Yahaya, I Tooyama, HA Damanhuri - Antioxidants, 2020 - mdpi.com
Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in
in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and …

Brain tocopherols related to Alzheimer's disease neuropathology in humans

MC Morris, JA Schneider, H Li, CC Tangney… - Alzheimer's & …, 2015 - Elsevier
Randomized trials of α-tocopherol supplements on cognitive decline are negative, whereas
studies of dietary tocopherols have shown benefit. We investigated these inconsistencies by …

Antioxidant enzyme activity and malondialdehyde levels can be modulated by Piper betle, tocotrienol rich fraction and Chlorella vulgaris in aging C57BL/6 mice

NS Aliahmat, MRM Noor, WJW Yusof, S Makpol… - Clinics, 2012 - SciELO Brasil
OBJECTIVE: The aim of this study was to determine the erythrocyte antioxidant enzyme
activity and the superoxide dismutase, catalase, glutathione peroxidase, and plasma …

Cognitive function improvement with astaxanthin and tocotrienol intake: A randomized, double-blind, placebo-controlled study

T Sekikawa, Y Kizawa, Y Li, T Takara - Journal of Clinical …, 2020 - jstage.jst.go.jp
抄録 We examined the effects of the mixed ingestion of astaxanthin derived from
Haematococcus pluvialis and tocotrienols on the cognitive function of healthy Japanese …

Safety and neuroprotective efficacy of palm oil and tocotrienol-rich fraction from palm oil: A systematic review

M Ismail, A Alsalahi, MU Imam, DJ Ooi, H Khaza'Ai… - Nutrients, 2020 - mdpi.com
Background: Several natural products have been reported to elicit beneficial effects against
neurodegenerative disorders due to their vitamin E contents. However, the neuroprotective …

Regulation of obesity and metabolic complications by gamma and delta tocotrienols

L Zhao, X Fang, MR Marshall, S Chung - Molecules, 2016 - mdpi.com
Tocotrienols (T3s) are a subclass of unsaturated vitamin E that have been extensively
studied for their anti-proliferative, anti-oxidative and anti-inflammatory properties in …

Levodopa improves learning and memory ability on global cerebral ischemia-reperfusion injured rats in the Morris water maze test

W Wang, L Liu, P Jiang, C Chen, T Zhang - Neuroscience letters, 2017 - Elsevier
Previous studies have shown that levodopa (L-dopa) for 1–7 days improved the
consciousness level of certain patients who suffered from ischemia-reperfusion injury and …

Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells

AT Tran, M Ramalinga, H Kedir, R Clarke… - European journal of …, 2015 - Springer
Introduction Tocomin® represents commercially available mixture of naturally occurring
tocotrienols (T3s) and tocopherols extracted from palm oil/palm fruits that possess powerful …