The HMG-CoA reductase inhibitors are a class of drugs also known as statins. These drugs
are effective and widely prescribed for the treatment of hypercholesterolemia and prevention …

Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …

The major burden of the human immunodeficiency (HIV) type 1 pandemic is nowadays
carried by women from sub-Saharan Africa. Differences in the manifestations of HIV-1 …

Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

Besides CYP2B6, other polymorphic enzymes contribute to efavirenz (EFV) interindividual
variability. This study was aimed at quantifying the impact of multiple alleles on EFV …

Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity:
in humans, genetic variations account for a relevant proportion of such variability. In the last …

Background Since the introduction of highly active antiretroviral therapy (HAART), morbidity
and mortality rates have sharply decreased among HIV-infected patients. Studies of possible …

Background: The impact of pregnancy on efavirenz (EFV) pharmacokinetics is unknown.
Methods: International Maternal Pediatric Adolescent AIDS Clinical Trials P1026s is an on …

In recent years, following the successful development of highly active antiretroviral therapy
(HAART), several studies have evaluated potential differences between men and women in …

Gender differences in treatment outcomes of 305 persons living with HIV receiving
antiretroviral treatment (ART) in Kabarole district, western Uganda, were evaluated. The …