RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Activating innate immunity in cancer cells through cytoplasmic nucleic acid sensing
pathways, a phenomenon known as “viral mimicry,” has emerged as an effective strategy to …

Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …

Abstract Aberrant DNA/RNA hybrids (R-loops) formed during transcription and replication
disturbances pose threats to genome stability. DHX9 is an RNA helicase involved in R-loop …

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …

Abstract The BRCA1–PALB2–BRCA2 axis plays essential roles in the cellular response to
DNA double-strand breaks (DSB), maintenance of genome integrity, and suppression of …

Abstract Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the
mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates …