In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Colorectal cancer is a complex disease resulting from the interaction of genetics,
epigenetics, and environmental factors. DNA methylation is frequently found in tumor …

Despite the effectiveness of imatinib, most gastrointestinal stromal tumors (GISTs) develop
resistance to the treatment, mainly due to the reactivation of KIT tyrosine kinase activity …

Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the
signaling network of the second messenger diacylglycerol. The three family members …

Background More than 90% of the mortality of triple-negative breast cancer (TNBC) patients
is attributed to cancer metastasis with organotropism. The lung is a frequent site of TNBC …

There is a need to improve diagnostic and therapeutic approaches to enhance the
prognosis of breast cancer, the most common malignancy worldwide. Membrane lipid …

Protein kinase D (PKD) family members play controversial roles in prostate cancer (PC).
Thus, PKD1 is nearly absent in advanced tumours, where PKD2 and PKD3 are upregulated …

The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been
repeatedly reported. Therefore, the search for novel PKD inhibitors and their evaluation as …

The protein kinase D (PKD) family is a family of serine-threonine kinases that are members
of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been …

Most gastrointestinal stromal tumors (GISTs) develop due to gain-of-function mutations in the
tyrosine kinase gene, KIT. We recently showed that mutant KIT mislocalizes to the Golgi area …