Rifamycin antibiotics and the mechanisms of their failure

RA Adams, G Leon, NM Miller, SP Reyes… - The Journal of …, 2021 - nature.com
Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for
their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many …

Biofilm-related infections in gram-positive bacteria and the potential role of the long-acting agent dalbavancin

A Oliva, S Stefani, M Venditti… - Frontiers in …, 2021 - frontiersin.org
Infections caused by Gram-positive bacteria are a major public health problem due to their
increasing resistance to antibiotics. Staphylococcus and Enterococcus species' resistance …

Liposomes as a Nanoplatform to Improve the Delivery of Antibiotics into Staphylococcus aureus Biofilms

M Ferreira, SN Pinto, F Aires-da-Silva, A Bettencourt… - Pharmaceutics, 2021 - mdpi.com
Staphylococcus aureus biofilm-associated infections are a major public health concern.
Current therapies are hampered by reduced penetration of antibiotics through biofilm and …

Controversy about the role of rifampin in biofilm infections: is it justified?

N Renz, A Trampuz, W Zimmerli - Antibiotics, 2021 - mdpi.com
Rifampin is a potent antibiotic against staphylococcal implant-associated infections. In the
absence of implants, current data suggest against the use of rifampin combinations. In the …

Model-based comparative analysis of rifampicin and rifabutin drug-drug interaction profile

V Tuloup, M France, R Garreau, N Bleyzac… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Rifamycins are widely used for treating mycobacterial and staphylococcal infections. Drug-
drug interactions (DDI) caused by rifampicin (RIF) are a major issue. We used a model …

Functional annotation of rhizospheric phageome of the wild plant species Moringa oleifera

RA Ashy, RS Jalal, HS Sonbol, MD Alqahtani… - Frontiers in …, 2023 - frontiersin.org
Introduction The study aims to describe phageome of soil rhizosphere of M. oleifera in terms
of the genes encoding CAZymes and other KEGG enzymes. Methods Genes of the …

Rifampin and cis-2-decenoic acid co-entrapment in solid lipid nanoparticles as an efficient nano-system with potent anti-biofilm activities

H Akhtari, BS Fazly Bazzaz… - Journal of …, 2021 - Springer
Purpose This study was performed to explore the physicochemical and anti-biofilm
properties of rifampin (Rif) and cis-2-decenoic acid (C2DA) co-entrapped in solid lipid …

Novel Use of Rifabutin and Rifapentine to Treat Methicillin-Resistant Staphylococcus aureus in a Rat Model of Foreign Body Osteomyelitis

MJ Karau, SM Schmidt-Malan, M Albano… - The Journal of …, 2020 - academic.oup.com
Background Owing to patient intolerance or drug interactions, alternative agents to rifampin
are needed for management of staphylococcal periprosthetic joint infection. In the current …

A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

MAT Blaskovich, KA Hansford, MS Butler… - Science translational …, 2022 - science.org
Drug-resistant Gram-positive bacterial infections are still a substantial burden on the public
health system, with two bacteria (Staphylococcus aureus and Streptococcus pneumoniae) …

Stability of non-ionic surfactant vesicles loaded with rifamycin S

V Marchianò, M Matos, I Marcet, MP Cabal, G Gutiérrez… - Pharmaceutics, 2022 - mdpi.com
These days, the eradication of bacterial infections is more difficult due to the mechanism of
resistance that bacteria have developed towards traditional antibiotics. One of the medical …