The duocarmycins (1 and 2) 1 belong to a small family of natural products (Figure 1) that
also include yatakemycin (3) 2 and CC-1065 (4). 3 Their exceptionally potent cytotoxic …

The duocarmycins and (+)-CC-1065 are amongst the most potent antitumour antibiotics
discovered to date and yet have not progressed into the clinic. The natural products are …

The examination of shortened, simplified, and extended analogs of duocarmycin SA is
described and constitutes a detailed study of the role of linked DNA binding subunit. In …

The synthesis and evaluation of a series of C3-substituted 1, 2, 9, 9a-tetrahydrocyclopropa
[c] benz [e] indol-4-one (CBI) analogues of the CC-1065 and duocarmycin alkylation …

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring
substituent effects within the first indole DNA binding subunit is detailed. In general …

The synthesis of 1, 2, 3, 4, 11, 11a-hexahydrocyclopropa [c] naphtho [2, 1− b] azepin-6-one
(CNA), a seven-membered C-ring analog of the alkylation subunits of CC-1065 and the …

The synthesis and chemical properties of 1, 2, 9, 9a-tetrahydro-1 H-cyclopropa [c] benz [e]
inden-4-one (CBIn, 10), a carbocyclic C-ring analogue of the alkylation subunits of CC-1065 …

A series of 3-substituted A-ring pyrrole compounds of duocarmycin were synthesized and
evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity …

The preparation and evaluation of both enantiomers of 5 are described and it constitutes an
analogue of CBI-TMI (4), the duocarmycins, and CC-1065 in which the amide linking the …

A series of A-ring pyrrole derivatives of duocarmycin bearing β-(5′, 6′, 7′-trimethoxy-2′-
indolyl) acryloyl group were synthesized, and evaluated for in vitro anticellular activity …