Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

N Tegtmeyer, M Neddermann, CI Asche… - Molecular …, 2017 - Wiley Online Library
Helicobacter pylori is a paradigm of persistent pathogens and major risk factor for
developing severe diseases including adenocarcinoma in the human stomach. An important …

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine

M Stein, P Ruggiero, R Rappuoli, F Bagnoli - Frontiers in immunology, 2013 - frontiersin.org
Helicobacter pylori colonizes the gastric mucosa of more than 50% of the human population,
causing chronic inflammation, which however is largely asymptomatic. Nevertheless, H …

Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity

SC Tran, MS McClain, TL Cover - Infection and Immunity, 2023 - Am Soc Microbiol
Helicobacter pylori strains containing the cag pathogenicity island (PAI) are associated with
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …

The implication of gastric microbiome in the treatment of gastric cancer

G Pappas-Gogos, K Tepelenis, F Fousekis, K Katsanos… - Cancers, 2022 - mdpi.com
Simple Summary Gastric cancer (GC) represents the fifth most common cancer worldwide.
Recent developments in PCR and metagenomics clarify that the stomach contains a …

[HTML][HTML] Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer

SY Chen, RG Zhang, GC Duan - Oncology reports, 2016 - spandidos-publications.com
Infection with Helicobacter pylori is the strongest risk factor for the development of chronic
gastritis, gastric ulcer and gastric carcinoma. The majority of the H. pylori-infected population …

Xenophagy in Helicobacter pylori‐ and Epstein–Barr virus‐induced gastric cancer

L Zhang, JJY Sung, J Yu, SC Ng… - The Journal of …, 2014 - Wiley Online Library
Abstract Helicobacter pylori and Epstein–Barr virus (EBV) account for roughly 80% and
10%, respectively, of gastric carcinomas worldwide. Autophagy is an evolutionarily …

Emerging mechanisms and treatment progress on liver metastasis of colorectal cancer

W Zheng, F Wu, K Fu, G Sun, G Sun, X Li… - OncoTargets and …, 2021 - Taylor & Francis
Colorectal cancer is currently the third largest malignant tumor in the world, with high new
cases and high mortality. Metastasis is one of the most common causes of death of …

Canonical and noncanonical roles of Par-1/MARK kinases in cell migration

JA McDonald - International review of cell and molecular biology, 2014 - Elsevier
The partitioning defective gene 1 (Par-1)/microtubule affinity-regulating kinase (MARK)
family of serine–threonine kinases have diverse cellular roles. Primary among these roles …

Role of bacteria in the incidence of common GIT cancers: the dialectical role of integrated bacterial DNA in human carcinogenesis

SK Elagan, SJ Almalki, MR Alharthi… - Infection and Drug …, 2021 - Taylor & Francis
Despite the wide medical knowledge about the direct role of many viruses in the
pathogenesis of certain cancers, there is still ambiguity and hazy vision about the direct role …

Morphological changes in human gastric epithelial cells induced by nuclear targeting of Helicobacter pylori urease subunit A

JH Lee, SH Jun, JM Kim, SC Baik, JC Lee - Journal of Microbiology, 2015 - Springer
Nuclear targeting of bacterial proteins and their pathological effects on host cells are an
emerging pathogenic mechanism in bacteria. We have previously reported that urease …