[HTML][HTML] Photodynamic therapy—current limitations and novel approaches
G Gunaydin, ME Gedik, S Ayan - Frontiers in Chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …
Cancer therapeutics based on diverse energy sources
Light-based phototherapy has been developed for cancer treatment owing to its non-
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …
Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …
Innovative strategies for hypoxic‐tumor photodynamic therapy
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback
associated with its oxygen‐dependent nature, which limits its effective use against hypoxic …
associated with its oxygen‐dependent nature, which limits its effective use against hypoxic …
Photodynamic therapy for hypoxic tumors: Advances and perspectives
Photodynamic therapy (PDT) has been a preferred clinical technology for treating superficial
tumors due to its advantages of high selectivity, non-invasiveness and negligible drug …
tumors due to its advantages of high selectivity, non-invasiveness and negligible drug …
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …
Nanotechnology for multimodal synergistic cancer therapy
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …
Supramolecular photosensitizers rejuvenate photodynamic therapy
X Li, S Lee, J Yoon - Chemical Society Reviews, 2018 - pubs.rsc.org
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT)
has become a clinically promising approach for the treatment of a wide range of cancers and …
has become a clinically promising approach for the treatment of a wide range of cancers and …
[HTML][HTML] Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for
malignant neoplasms. However, current systems are highly dependent on oxygen status …
malignant neoplasms. However, current systems are highly dependent on oxygen status …
Nanozyme decorated metal–organic frameworks for enhanced photodynamic therapy
Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of
cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by …
cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by …