[HTML][HTML] Photodynamic therapy—current limitations and novel approaches

G Gunaydin, ME Gedik, S Ayan - Frontiers in Chemistry, 2021 - frontiersin.org
Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the
excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be …

Cancer therapeutics based on diverse energy sources

S Son, J Kim, J Kim, B Kim, J Lee, Y Kim, M Li… - Chemical Society …, 2022 - pubs.rsc.org
Light-based phototherapy has been developed for cancer treatment owing to its non-
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …

Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia

S Kuang, F Wei, J Karges, L Ke, K Xiong… - Journal of the …, 2022 - ACS Publications
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …

Innovative strategies for hypoxic‐tumor photodynamic therapy

X Li, N Kwon, T Guo, Z Liu… - Angewandte Chemie …, 2018 - Wiley Online Library
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback
associated with its oxygen‐dependent nature, which limits its effective use against hypoxic …

Photodynamic therapy for hypoxic tumors: Advances and perspectives

L Huang, S Zhao, J Wu, L Yu, N Singh, K Yang… - Coordination Chemistry …, 2021 - Elsevier
Photodynamic therapy (PDT) has been a preferred clinical technology for treating superficial
tumors due to its advantages of high selectivity, non-invasiveness and negligible drug …

Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

W Tang, W Fan, J Lau, L Deng, Z Shen… - Chemical Society …, 2019 - pubs.rsc.org
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

Nanotechnology for multimodal synergistic cancer therapy

W Fan, B Yung, P Huang, X Chen - Chemical reviews, 2017 - ACS Publications
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …

Supramolecular photosensitizers rejuvenate photodynamic therapy

X Li, S Lee, J Yoon - Chemical Society Reviews, 2018 - pubs.rsc.org
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT)
has become a clinically promising approach for the treatment of a wide range of cancers and …

[HTML][HTML] Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Z Wang, Y Zhang, E Ju, Z Liu, F Cao, Z Chen… - Nature …, 2018 - nature.com
Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for
malignant neoplasms. However, current systems are highly dependent on oxygen status …

Nanozyme decorated metal–organic frameworks for enhanced photodynamic therapy

Y Zhang, F Wang, C Liu, Z Wang, LH Kang, Y Huang… - ACS …, 2018 - ACS Publications
Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of
cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by …