Diabetes often leads to a number of complications involving brain function, including
cognitive decline and depression. In addition, depression is a risk factor for developing …

The adult mammalian brain contains a population of neural stem cells that can give rise to
neurons, astrocytes, and oligodendrocytes and are thought to be involved in certain forms of …

It is now well established that the mammalian brain has the capacity to produce new
neurons into adulthood. One such region that provides the proper milieu to sustain …

The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …

Controversy regarding estrogen action in the brain remains at the forefront of basic,
translational and clinical science for women's health. Here, I provide an integrative analysis …

A theoretical framework is proposed to gain insight into the pathogenesis of major
depressive disorder (MDD). Despite being a relatively weak argument, the neurogenesis …

Type 1 diabetes (T1D) is accompanied by a “diabetic encephalopathy” including
hypersensitivity to stress, increased risk of stroke, dementia and cognitive impairment. In …

Background Several brain disturbances have been described in association to type 1
diabetes in humans. In animal models, hippocampal pathological changes were reported …

Objectives–Adult neurogenesis in dentate gyrus (DG) is an evolutionarily preserved trait in
most mammals examined thus far. Neuronal proliferation and subsequent integration of new …

Over the past decade our recognition that estrogens function as important neurotrophic and
neuroprotective factors has grown rapidly. Accumulating evidence from basic science …