Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
EMT and MET: necessary or permissive for metastasis?
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …
Focus on the emerging new fields of network physiology and network medicine
Despite the vast progress and achievements in systems biology and integrative physiology
in the last decades, there is still a significant gap in understanding the mechanisms through …
in the last decades, there is still a significant gap in understanding the mechanisms through …
Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks
Elucidating the design principles of regulatory networks driving cellular decision-making has
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …
fundamental implications in mapping and eventually controlling cell-fate decisions. Despite …
[HTML][HTML] Coupling the modules of EMT and stemness: A tunable 'stemness window'model
Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate
secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal …
secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal …
Understanding the principles of pattern formation driven by notch signaling by integrating experiments and theoretical models
Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …
The physics of cellular decision making during epithelial–mesenchymal transition
The epithelial–mesenchymal transition (EMT) is a process by which cells lose epithelial
traits, such as cell–cell adhesion and apico-basal polarity, and acquire migratory and …
traits, such as cell–cell adhesion and apico-basal polarity, and acquire migratory and …
Phenotypic plasticity, bet-hedging, and androgen independence in prostate cancer: role of non-genetic heterogeneity
MK Jolly, P Kulkarni, K Weninger, J Orban… - Frontiers in …, 2018 - frontiersin.org
It is well known that genetic mutations can drive drug resistance and lead to tumor relapse.
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …