Cognitive adverse effects of chemotherapy and immunotherapy: are interventions within reach?

SB Schagen, AS Tsvetkov, A Compter… - Nature Reviews …, 2022 - nature.com
One in three people will be diagnosed with cancer during their lifetime. The community of
cancer patients is growing, and several common cancers are becoming increasingly …

Metformin, cognitive function, and changes in the gut microbiome

M Rosell-Díaz, JM Fernández-Real - Endocrine reviews, 2024 - academic.oup.com
The decline in cognitive function and the prevalence of neurodegenerative disorders are
among the most serious threats to health in old age. The prevalence of dementia has …

Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex

T Shao, J Huang, Y Zhao, W Wang, X Tian… - Translational …, 2023 - nature.com
Cognitive impairment is a core feature of schizophrenia, which is aggravated by
antipsychotics-induced metabolic disturbance and lacks effective pharmacologic treatments …

Metformin, age-related cognitive decline, and brain pathology

A Sood, AW Capuano, RS Wilson, LL Barnes… - Neurobiology of …, 2024 - Elsevier
The objective of this study was to evaluate the relation of metformin with change in cognition
and brain pathology. During a mean of 8 years (SD= 5.5) of annual follow-up visits …

The effect of metformin on cognitive function: a systematic review and meta-analysis

O Tabatabaei Malazy, F Bandarian… - Journal of …, 2022 - journals.sagepub.com
Most people are familiar with metformin as a diabetic treatment option. Different positive
benefits have been found for it, in addition to its anti-diabetes properties. Cognitive function …

The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: An open-labelled randomized …

HE Barakat, RRS Hussein, AA Elberry, MA Zaki… - Scientific Reports, 2022 - nature.com
Recently, several clinical trials have attempted to find evidence that supports the anticancer
use of metformin in breast cancer (BC) patients. The current study evaluates the anticancer …

Metformin and cognition from the perspectives of sex, age, and disease

K Chaudhari, CD Reynolds, SH Yang - Geroscience, 2020 - Springer
Metformin is the safest and the most widely prescribed first-line therapy for managing
hyperglycemia due to different underlying causes, primarily type 2 diabetes mellitus. In …

Disrupting the mood and obesity cycle: the potential role of metformin

SN Doan, SK Patel, B Xie, RA Nelson, LD Yee - Obesities, 2023 - mdpi.com
Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised
metabolic health and psychological functioning worsen clinical outcomes, diminish quality of …

Investigating the pro-cognitive and anti-depressant efficacy of metformin: A systematic review and meta-analysis of randomised controlled trials

A Nibber, H Singh, P Burnet, B Lennox… - Journal of Affective …, 2022 - Elsevier
Background The preclinical and clinical data regarding the efficacy of metformin as a pro-
cognitive and anti-depressant therapy is mixed. We conducted a systematic review and meta …

Effective non-pharmacological interventions for cancer related cognitive impairment in adults (excluding central nervous system or head and neck cancer): systematic …

L Mackenzie, K Marshall - EuropEan Journal of physical and …, 2021 - pmc.ncbi.nlm.nih.gov
INTRODUCTION Cancer-related cognitive impairment (CRCI) is prevalent in cancer
survivors, and impairments affect daily living tasks and overall wellbeing. This review aimed …