Within-host evolution of human influenza virus
The rapid global evolution of influenza virus begins with mutations that arise de novo in
individual infections, but little is known about how evolution occurs within hosts. We review …
individual infections, but little is known about how evolution occurs within hosts. We review …
Within-host viral diversity: a window into viral evolution
AS Lauring - Annual Review of Virology, 2020 - annualreviews.org
The evolutionary dynamics of a virus can differ within hosts and across populations. Studies
of within-host evolution provide an important link between experimental studies of virus …
of within-host evolution provide an important link between experimental studies of virus …
[HTML][HTML] An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar
How viruses evolve within hosts can dictate infection outcomes; however, reconstructing this
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …
[HTML][HTML] Patterns of within-host genetic diversity in SARS-CoV-2
Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become
a major public health focus for many governments around the world. The modest mutation …
a major public health focus for many governments around the world. The modest mutation …
Human cytomegalovirus genomes sequenced directly from clinical material: variation, multiple-strain infection, recombination, and gene loss
The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …
from clinical pathology samples were investigated, focusing on variation, multiple-strain …
Linking influenza virus evolution within and between human hosts
Influenza viruses rapidly diversify within individual human infections. Several recent studies
have deep-sequenced clinical influenza infections to identify viral variation within hosts, but …
have deep-sequenced clinical influenza infections to identify viral variation within hosts, but …
[HTML][HTML] Applying next-generation sequencing to unravel the mutational landscape in viral quasispecies
Next-generation sequencing (NGS) has revolutionized the scale and depth of biomedical
sciences. Because of its unique ability for the detection of sub-clonal variants within …
sciences. Because of its unique ability for the detection of sub-clonal variants within …
Measurements of intrahost viral diversity require an unbiased diversity metric
L Zhao, CJR Illingworth - Virus Evolution, 2019 - academic.oup.com
Viruses exist within hosts at large population sizes and are subject to high rates of mutation.
As such, viral populations exhibit considerable sequence diversity. A variety of summary …
As such, viral populations exhibit considerable sequence diversity. A variety of summary …
A2B-COVID: a tool for rapidly evaluating potential SARS-CoV-2 transmission events
Identifying linked cases of infection is a critical component of the public health response to
viral infectious diseases. In a clinical context, there is a need to make rapid assessments of …
viral infectious diseases. In a clinical context, there is a need to make rapid assessments of …
[HTML][HTML] Drivers of within-host genetic diversity in acute infections of viruses
Genetic diversity is the fuel of evolution and facilitates adaptation to novel environments.
However, our understanding of what drives differences in the genetic diversity during the …
However, our understanding of what drives differences in the genetic diversity during the …