Dissecting and visualizing the functional diversity of cardiac macrophages
Cardiac macrophages represent a functionally diverse population of cells involved in
cardiac homeostasis, repair, and remodeling. With recent advancements in single-cell …
cardiac homeostasis, repair, and remodeling. With recent advancements in single-cell …
The molecular mechanisms of cardiac development and related diseases
Y Li, J Du, S Deng, B Liu, X Jing, Y Yan, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Cardiac development is a complex and intricate process involving numerous molecular
signals and pathways. Researchers have explored cardiac development through a long …
signals and pathways. Researchers have explored cardiac development through a long …
Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues
The fabrication of complex and stable vasculature in engineered cardiac tissues represents
a significant hurdle towards building physiologically relevant models of the heart. Here, we …
a significant hurdle towards building physiologically relevant models of the heart. Here, we …
Development and Application of 3D Cardiac Tissues Derived from Human Pluripotent Stem Cells
Recently human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have become an
attractive platform to evaluate drug responses for cardiotoxicity testing and disease …
attractive platform to evaluate drug responses for cardiotoxicity testing and disease …
Engineered macrophages: an “Intelligent Repair” cellular machine for heart injury
Z Zhang, H Du, W Gao, D Zhang - Cell Regeneration, 2024 - Springer
Macrophages are crucial in the heart's development, function, and injury. As part of the
innate immune system, they act as the first line of defense during cardiac injury and repair …
innate immune system, they act as the first line of defense during cardiac injury and repair …
Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche
AC Vollmers, SZ Wu, A Altieri, EE McCartney, H Bender… - bioRxiv, 2024 - biorxiv.org
Fibroblasts are present in all tissues and are crucial for maintaining tissue homeostasis. We
previously identified fibroblasts marked by Dermatopontin (Dpt) but their role in supporting …
previously identified fibroblasts marked by Dermatopontin (Dpt) but their role in supporting …
Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions
Interactions between the developing heart and the embryonic immune system are essential
for proper cardiac development and maintaining homeostasis, with disruptions linked to …
for proper cardiac development and maintaining homeostasis, with disruptions linked to …
Digital Light Processing 3D Printing enables High Throughput Fabrication of Human Engineered Heart Tissues for Disease Modeling
3D in vitro engineered heart tissue (EHT) models recapitulate aspects of native cardiac
physiology but are often limited by scalability, cost, and reproducibility. Here, we report a …
physiology but are often limited by scalability, cost, and reproducibility. Here, we report a …
Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms
Cardiovascular disease stands as the leading cause of death globally, claiming
approximately 19 million lives in 2020. On the contrary, the development of cardiovascular …
approximately 19 million lives in 2020. On the contrary, the development of cardiovascular …
Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
The intricate anatomical structure and high cellular density of the myocardium complicate
the bioengineering of perfusable vascular networks within cardiac tissues. In vivo neonatal …
the bioengineering of perfusable vascular networks within cardiac tissues. In vivo neonatal …