Ionic liquids: new forms of active pharmaceutical ingredients with unique, tunable properties

JL Shamshina, RD Rogers - Chemical Reviews, 2023 - ACS Publications
This Review aims to summarize advances over the last 15 years in the development of
active pharmaceutical ingredient ionic liquids (API-ILs), which make up a prospective game …

Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Biocompatible ionic liquids and their applications in pharmaceutics

RM Moshikur, MR Chowdhury, M Moniruzzaman… - Green …, 2020 - pubs.rsc.org
Ionic liquids (ILs) have been used as solvents or materials, or both, in many applications,
including pharmaceutics and medicine due to their exceptional properties consisting of the …

50 years of oral lipid-based formulations: provenance, progress and future perspectives

OM Feeney, MF Crum, CL McEvoy, NL Trevaskis… - Advanced drug delivery …, 2016 - Elsevier
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Ionic liquids as a potential tool for drug delivery systems

N Adawiyah, M Moniruzzaman, S Hawatulaila… - …, 2016 - pubs.rsc.org
The pharmaceutical industries face a series of challenges in the delivery of many newly
developed drug molecules because of their low solubility, bioavailability, stability and …

Chemistry: Develop ionic liquid drugs

JL Shamshina, SP Kelley, G Gurau, RD Rogers - Nature, 2015 - nature.com
Chemistry: Develop ionic liquid drugs | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation

RM Moshikur, MR Chowdhury, R Wakabayashi… - Journal of Molecular …, 2020 - Elsevier
The development of non-toxic ionic liquid-based active pharmaceutical ingredients (IL-APIs)
for effective topical drug delivery is still challenging. The properties of IL-APIs can be …

Transformation of hydrophilic drug into oil-miscible ionic liquids for transdermal drug delivery

R Md Moshikur, IM Shimul, S Uddin… - … Applied Materials & …, 2022 - ACS Publications
The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability
to permeate the skin; formulation with oil media is difficult without adding chemical …

Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation

RM Moshikur, MR Chowdhury, R Wakabayashi… - Journal of Molecular …, 2019 - Elsevier
The technological utility of active pharmaceutical ingredients (APIs) is enormously improved
when they are converted into ionic liquids (ILs). API-ILs possess better aqueous solubility …

Imidazole and imidazolium antibacterial drugs derived from amino acids

A Valls, JJ Andreu, E Falomir, SV Luis, E Atrián-Blasco… - Pharmaceuticals, 2020 - mdpi.com
The antibacterial activity of imidazole and imidazolium salts is highly dependent upon their
lipophilicity, which can be tuned through the introduction of different hydrophobic …