Pathogenesis of respiratory viral and fungal coinfections
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
First contact: the role of respiratory cilia in host-pathogen interactions in the airways
LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study
S Feys, SM Gonçalves, M Khan, S Choi… - The Lancet …, 2022 - thelancet.com
Background Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated
pulmonary aspergillosis (CAPA) affect about 15% of critically ill patients with influenza or …
pulmonary aspergillosis (CAPA) affect about 15% of critically ill patients with influenza or …
Mechanisms of fungal dissemination
AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …
million fungal species worldwide, but less than 1% are known to infect humans. Most of …
The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells
J Günther, HM Seyfert - Seminars in immunopathology, 2018 - Springer
Epithelial tissues cover most of the external and internal surfaces of the body and its organs.
Inevitably, these tissues serve as first line of defence against inorganic, organic, and …
Inevitably, these tissues serve as first line of defence against inorganic, organic, and …
Mast cells in the skin: defenders of integrity or offenders in inflammation?
Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …
that may even culminate in life-threatening anaphylactic shock syndromes. However …
Pathogenicity and virulence of Aspergillus fumigatus
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …
cause of morbidity and mortality globally. Compromised lung defences arising from …
Pathophysiological aspects of Aspergillus colonization in disease
Aspergillus colonization of the lower respiratory airways is common in normal people, and of
little clinical significance. However, in some patients, colonization is associated with severe …
little clinical significance. However, in some patients, colonization is associated with severe …
Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease
M Bertuzzi, GE Hayes, UJ Icheoku, N Van Rhijn… - Journal of Fungi, 2018 - mdpi.com
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores …
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores …
Modulation of innate immunity in airway epithelium for host-directed therapy
IT Myszor, GH Gudmundsson - Frontiers in Immunology, 2023 - frontiersin.org
Innate immunity of the mucosal surfaces provides the first-line defense from invading
pathogens and pollutants conferring protection from the external environment. Innate …
pathogens and pollutants conferring protection from the external environment. Innate …