Chronic pain is a common and debilitating condition with a huge social and economic
burden worldwide. Currently, available drugs in clinics are not adequately effective and …

The extent of gut inflammation depends largely on the gut barrier's integrity and enteric
neuroimmune interactions. However, the factors and molecular mechanisms that regulate …

In nematode Caenorhabditis elegans, exposure to polystyrene nanoparticles (PS-NPs) at
predicted environmental concentrations can cause induction of transgenerational toxicity …

Patients with inflammatory bowel disease often experience ongoing pain even after
achieving mucosal healing (ie, post-inflammatory pain). Factors related to the brain–gut axis …

Early life stress (ELS) disposes to functional gastrointestinal diseases in adult, such as
irritable bowel syndrome (IBS). Maternal separation (MS) is a well-known animal model of …

Irritable bowel syndrome (IBS) is a common refractory disease. Chinese medicine (CM) has
remarkable efficacy and advantages on the treatment of IBS. This review summarized the …

To understand the role of intestinal mucosal microbiota on mental stress-related diarrhoea,
we collected the intestinal mucosa of mice treated with Folium senna extract gavage …

Background Enteric nervous system (ENS) has been closely associated with the neuro-
immune response and is currently considered a reliable target for intestinal inflammation …

Abstract Background and Objective The relationship between chronic daily headache
(CDH), depression symptoms, and brain volume remains unclear. Methods To investigate …

Recent studies have shown that the ephrin/Eph signaling pathway may contribute to the
pathology of neuropathic pain. Drugs like progesterone may be used to counteract both …