Single-molecule localization microscopy in eukaryotes

M Sauer, M Heilemann - Chemical reviews, 2017 - ACS Publications
Super-resolution fluorescence imaging by photoactivation or photoswitching of single
fluorophores and position determination (single-molecule localization microscopy, SMLM) …

The presynaptic active zone

TC Südhof - Neuron, 2012 - cell.com
Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

[HTML][HTML] Non-canonical odor coding in the mosquito

M Herre, OV Goldman, TC Lu, G Caballero-Vidal, Y Qi… - Cell, 2022 - cell.com
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including
dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor …

[HTML][HTML] Sleep loss can cause death through accumulation of reactive oxygen species in the gut

A Vaccaro, YK Dor, K Nambara, EA Pollina, C Lin… - Cell, 2020 - cell.com
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

A complete electron microscopy volume of the brain of adult Drosophila melanogaster

Z Zheng, JS Lauritzen, E Perlman, CG Robinson… - Cell, 2018 - cell.com
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

[HTML][HTML] A GAL4-driver line resource for Drosophila neurobiology

A Jenett, GM Rubin, TTB Ngo, D Shepherd, C Murphy… - Cell reports, 2012 - cell.com
We established a collection of 7,000 transgenic lines of Drosophila melanogaster.
Expression of GAL4 in each line is controlled by a different, defined fragment of genomic …

Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system

A Nern, BD Pfeiffer, GM Rubin - Proceedings of the …, 2015 - National Acad Sciences
We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …

[HTML][HTML] A systematic nomenclature for the insect brain

K Ito, K Shinomiya, M Ito, JD Armstrong, G Boyan… - Neuron, 2014 - cell.com
Despite the importance of the insect nervous system for functional and developmental
neuroscience, descriptions of insect brains have suffered from a lack of uniform …

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

S Nagarkar-Jaiswal, PT Lee, ME Campbell, K Chen… - elife, 2015 - elifesciences.org
Here, we document a collection of∼ 7434 MiMIC (Minos Mediated Integration Cassette)
insertions of which 2854 are inserted in coding introns. They allowed us to create a library of …

A genetic, genomic, and computational resource for exploring neural circuit function

FP Davis, A Nern, S Picard, MB Reiser, GM Rubin… - Elife, 2020 - elifesciences.org
The anatomy of many neural circuits is being characterized with increasing resolution, but
their molecular properties remain mostly unknown. Here, we characterize gene expression …