[HTML][HTML] Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …
is associated with both functional biology and the development of a number of disorders …
Nucleation and growth of amino acid and peptide supramolecular polymers through liquid–liquid phase separation
The transition of peptides and proteins from the solution phase into fibrillar structures is a
general phenomenon encountered in functional and aberrant biology and is increasingly …
general phenomenon encountered in functional and aberrant biology and is increasingly …
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …
considered only as pathological aggregates implicated in human neurodegenerative …
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
[HTML][HTML] Secondary nucleation in amyloid formation
M Törnquist, TCT Michaels, K Sanagavarapu… - Chemical …, 2018 - pubs.rsc.org
Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …
same peptide or protein has emerged in the past two decades as a major pathway for both …
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi… - Proceedings of the …, 2013 - National Acad Sciences
The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42
into amyloid fibrils and plaques has emerged as a central feature of the onset and …
into amyloid fibrils and plaques has emerged as a central feature of the onset and …
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar… - Proceedings of the …, 2014 - National Acad Sciences
The formation of amyloid fibrils by the intrinsically disordered protein α-synuclein is a
hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of …
hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of …
[HTML][HTML] Structure and aggregation mechanisms in amyloids
ZL Almeida, RMM Brito - Molecules, 2020 - mdpi.com
The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Abstract α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …